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XNKCC2: Kidney specific Na-K-Cl cotransporter. Defects in this gene cause Bartter's syndrome in humans, a hypokalaemic alkalosis. Expressed very strongly in only the early distal segment.
Click on images to view enlargements. A pronephric tubule nomenclature figure is available.
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| Stage 28. | Stage 32, double stain- NKCC2 is black, ATPase is green. | Stage 32, same as embryo on the left except with reflected lighting. | Stage 33 |
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| Stage 35 | Stage 38 | Stage 40 | Stage 38, double stain. NKCC2 is red, and XNBC1 is green. Wholemount FISH. |
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Stage 42 (left) |
| Generated by: | Original description: | ||
| Agencourt: adult X.laevis kidney. Lib Name: NICHD_XGC_Kid1 | Zhou, X. and Vize, P.D. (2004). Proximo-distal specialization of epithelial transport processes within the Xenopus pronephric tubules. Developmental Biology 271: 322-338. | ||
| Images submitted by: | Sequence | ||
| Peter Vize | GenBank BU905556 | ||
| Probe available from: | Other papers by: | ||
| Peter Vize or IMAGE #4033317 | Peter Vize | ||
| probe details: | Other papers on: | ||
| plasmid: pCMV SPORT6 vector | cut with : | transcribe with : | pronephroi / Xenopus cotransporters |
| IMAGE 4033317 | SmaI | T7 | |
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