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XB-ART-46474
Science December 21, 2012; 338 (6114): 1587-93.

The evolutionary landscape of alternative splicing in vertebrate species.

Barbosa-Morais NL , Irimia M , Pan Q , Xiong HY , Gueroussov S , Lee LJ , Slobodeniuc V , Kutter C , Watt S , Colak R , Kim T , Misquitta-Ali CM , Wilson MD , Kim PM , Odom DT , Frey BJ , Blencowe BJ .


Abstract
How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity between vertebrate lineages, with the highest complexity in primates. Within 6 million years, the splicing profiles of physiologically equivalent organs diverged such that they are more strongly related to the identity of a species than they are to organ type. Most vertebrate species-specific splicing patterns are cis-directed. However, a subset of pronounced splicing changes are predicted to remodel protein interactions involving trans-acting regulators. These events likely further contributed to the diversification of splicing and other transcriptomic changes that underlie phenotypic differences among vertebrate species.

PubMed ID: 23258890
Article link: Science
Grant support: [+]


GEO Series: GSE41338: Xenbase,  NCBI
References :
Papasaikas, Evolution. Splicing in 4D. 2012, Pubmed