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In vertebrates, the readily apparent left/right (L/R) anatomical asymmetries of the internal organs can be traced to molecular events initiated at or near the time of gastrulation. However, the earliest steps of this process do not seem to be universally conserved. In particular, how this axis is first defined in chicks has remained problematic. Here we show that asymmetric cell rearrangements take place within chick embryos, creating a leftward movement of cells around the node. It is the relative displacement of cells expressing sonic hedgehog (Shh) and fibroblast growth factor 8 (Fgf8) that is responsible for establishing their asymmetric expression patterns. The creation of asymmetric expression domains as a passive effect of cell movements represents an alternative strategy for breaking L/R symmetry in gene activity.
Cui,
Rotation of organizer tissue contributes to left-right asymmetry.
2009, Pubmed
Cui,
Rotation of organizer tissue contributes to left-right asymmetry.
2009,
Pubmed
Dathe,
Morphological left-right asymmetry of Hensen's node precedes the asymmetric expression of Shh and Fgf8 in the chick embryo.
2002,
Pubmed
Essner,
Conserved function for embryonic nodal cilia.
2002,
Pubmed
,
Xenbase
Kirby,
Hensen's node gives rise to the ventral midline of the foregut: implications for organizing head and heart development.
2003,
Pubmed
Lee,
Morphogenesis of the node and notochord: the cellular basis for the establishment and maintenance of left-right asymmetry in the mouse.
2008,
Pubmed
Levin,
A molecular pathway determining left-right asymmetry in chick embryogenesis.
1995,
Pubmed
Levin,
Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning.
2002,
Pubmed
,
Xenbase
Levin,
Left-right asymmetry in embryonic development: a comprehensive review.
2005,
Pubmed
Marlow,
Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements.
2002,
Pubmed
,
Xenbase
Raya,
Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration.
2006,
Pubmed
Wei,
Rho kinases play an obligatory role in vertebrate embryonic organogenesis.
2001,
Pubmed
Yin,
The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation.
2009,
Pubmed
