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The transcription factors GATA4, GATA5 and GATA6 play important roles in heartmuscle differentiation. The data presented in this article are related to the research article entitled "Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis" (Afouda et al., 2017) [1]. The present study identifies genes regulated by these individual cardiogenic GATA factors using genome-wide transcriptomics analysis. We have presented genes that are specifically regulated by each of them, as well those regulated by either of them. The gene ontology terms (GO) associated with the genes differentially affected are also presented. The data set will allow further investigations on the gene regulatory network downstream of individual cardiogenic GATA factors during cardiac muscle formation.
Fig. 1.Venn diagrams of numbers of genes that are differentially expressed compared to Activin-injected control with at least a two-fold reduction in expression and an adjusted p value of 0.05. A: gata-dependent genes with decreased expression insingle gata4, gata5 or gata6 knockdown, respectively (for list of genes, seeTable 1). B: gata dependent genes with decreasedexpression in triple gata4, gata5 or gata6 knockdown compared to those with decreased expression in single gata4, gata5 and gata6 knockdown, respectively (for list of genes, seeTable 2).
Afouda,
Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis.
2018, Pubmed,
Xenbase
Afouda,
Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis.
2018,
Pubmed
,
Xenbase
Afouda,
Stem-cell-like embryonic explants to study cardiac development.
2012,
Pubmed
,
Xenbase
Afouda,
GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos.
2005,
Pubmed
,
Xenbase
Afouda,
GATA transcription factors integrate Wnt signalling during heart development.
2008,
Pubmed
,
Xenbase
Afouda,
Different requirements for GATA factors in cardiogenesis are mediated by non-canonical Wnt signaling.
2011,
Pubmed
,
Xenbase
Haworth,
GATA4 and GATA5 are essential for heart and liver development in Xenopus embryos.
2008,
Pubmed
,
Xenbase
Kim,
HISAT: a fast spliced aligner with low memory requirements.
2015,
Pubmed
Liao,
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.
2014,
Pubmed
Love,
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.
2014,
Pubmed
Peterkin,
GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation.
2003,
Pubmed
,
Xenbase
Zhang,
SOX7 and SOX18 are essential for cardiogenesis in Xenopus.
2005,
Pubmed
,
Xenbase