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XB-ART-10041
Neuroreport 2000 Oct 20;1115:3357-60. doi: 10.1097/00001756-200010200-00019.
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Toxic effect of the beta-amyloid precursor protein C-terminus fragment and Na+/Ca2+ gradients.

Bryan-Sisneros AA , Fraser SP , Suh YH , Djamgoz MB .


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There is evidence to suggest that certain metabolic fragments of the beta-amyloid precursor protein (betaAPP) containing the whole of the beta-amyloid (Abeta) sequence are toxic to cells. We showed previously that the 105-amino acid C-terminal peptide (CT105) fragment, incorporating Abeta, is particularly toxic to Xenopus oocytes as well as to mammalian neurons. Here, we investigated the contributions of Na+ and Ca2+ gradients to intracellular CT105-induced toxicity in oocytes, monitored by measuring the membrane resting potential. The concentration gradients of Na+ and Ca2+ were manipulated to determine the involvement of the trans-membrane concentration gradients of these ions in the mode of action of CT105. The results suggested that Na+ influx and intracellular events are mainly responsible for the observed CT105-induced toxicity.

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Species referenced: Xenopus
Genes referenced: app