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XB-ART-104
Immunity July 1, 2006; 25 (1): 79-91.

The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.

Atherly LO , Lucas JA , Felices M , Yin CC , Reiner SL , Berg LJ .


Abstract
The Tec family tyrosine kinases, Itk and Rlk, are expressed in thymocytes and peripheral T cells and regulate thresholds of T cell receptor signaling. Yet little is known about the specific role of Itk- and Rlk-dependent signals in CD8(+) T cell maturation. We show here that Itk(-/-) and Rlk(-/-)Itk(-/-) mice were nearly devoid of conventional CD8(+) T cells and, instead, contained a large population of CD8(+) T cells that bear striking similarity to lineages of innate lymphocytes. Itk(-/-) and Rlk(-/-)Itk(-/-) CD8(+) thymocytes and T cells were CD44(hi), CD122(+), and NK1.1(+); were able to produce interferon-gamma directly ex vivo; and were dependent on interleukin-15. Itk(-/-) and Rlk(-/-)Itk(-/-) CD8(+) thymocytes expressed abundant transcripts for the T box transcription factor, eomesodermin, correlating with their phenotype and function. These data indicate a critical role for Itk and Rlk in conventional CD8(+) T cell development in the thymus.

PubMed ID: 16860759
Article link: Immunity
Grant support: [+]
Genes referenced: b3gat1l eomes itk nr4a3 tec txk

References:
Hogquist, 2006, Pubmed


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