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XB-ART-10438
Mech Dev. September 1, 2000; 96 (2): 259-62.

Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes.



Abstract
The homeodomain transcription factor Nkx2-1 (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon.

PubMed ID: 10960795
Article link: Mech Dev.
Grant support: HL64763 NHLBI NIH HHS , HL64764 NHLBI NIH HHS

Genes referenced: nkx2-1 nkx2-4


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