Exp Cell Res 2006 Mar 10;3125:684-93. doi: 10.1016/j.yexcr.2005.10.018.

Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis.

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Small vertebrate organisms have emerged as key players in the post-genomic era for the functional characterization of novel genes on a high-throughput scale. In this context, the zebrafish embryos and Xenopus tadpoles represent attractive and valuable models to rapidly identify and characterize novel genes involved in angiogenesis and lymphangiogenesis-a significant task with a consequent impact on the design of more effective therapeutic strategies. The advantages of these two models will be discussed in the present review.

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