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Development January 1, 2006; 133 (1): 15-20.

Vg 1 is an essential signaling molecule in Xenopus development.

Birsoy B , Kofron M , Schaible K , Wylie C , Heasman J .

Xenopus Vg 1, a transforming growth factor beta (Tgfbeta) family member, was one of the first maternally localized mRNAs identified in vertebrates. Its restriction to the vegetal pole of the egg made it the ideal candidate to be the mesoderm-inducing signal released by vegetal cells, but its function in vivo has never been resolved. We show that Vg 1 is essential for Xenopus embryonic development, and is required for mesoderm induction and for the expression of several key Bmp antagonists. Although the original Vg 1 transcript does not rescue Vg 1-depleted embryos, we report that a second allele is effective. This work resolves the mystery of Vg 1 function, and shows it to be an essential maternal regulator of embryonic patterning.

PubMed ID: 16308332
Article link: Development
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: cer1 chrd.1 fgf8 gdf1 nodal1 nodal5.2 nodal5.4 nog smad2 tub vegt
Morpholinos: gdf1 MO1

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