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Dev Dyn August 1, 2000; 218 (4): 615-27.

Development of the pancreas in Xenopus laevis.

Xenopus embryos have several experimental advantages for studying development. Although these advantages have traditionally been used to elucidate mechanisms of early development, they can also be exploited to investigate issues later in development such as organogenesis. We have begun to study pancreatic organogenesis in Xenopus. Using histological and molecular marker analysis, we characterized the anatomy of the developing pancreas in Xenopus embryos from the time of initial pancreatic rudiment formation to the time when the tadpole starts to feed. We examined the expression of various endocrine hormones, exocrine gene products, and pancreatic transcription factors. Interestingly, the endocrine hormone insulin has restricted expression in the dorsal pancreas. Investigation of pancreatic specification during gastrulation demonstrates that insulin expression is regionalized along the dorsoventral axis early in development.

PubMed ID: 10906780
Article link: Dev Dyn

Species referenced: Xenopus laevis
Genes referenced: a2m cpa1 eef1a2 fubp1 gcg ins isl1 ncam1 neurod1 pax6 pdx1 sst.1
Antibodies: Cpa1 Ab1 Gcg Ab1 Ins Ab1 Sst Ab1

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