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XB-ART-10683
Genes Dev July 15, 2000; 14 (14): 1741-9.

Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.

Tago K , Nakamura T , Nishita M , Hyodo J , Nagai S , Murata Y , Adachi S , Ohwada S , Morishita Y , Shibuya H , Akiyama T .


Abstract
Wnt signaling has an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Here, we identify a novel beta-catenin-interacting protein, ICAT, that was found to inhibit the interaction of beta-catenin with TCF-4 and represses beta-catenin-TCF-4-mediated transactivation. Furthermore, ICAT inhibited Xenopus axis formation by interfering with Wnt signaling. These results suggest that ICAT negatively regulates Wnt signaling via inhibition of the interaction between beta-catenin and TCF and is integral in development and cell proliferation.

PubMed ID: 10898789
PMC ID: PMC316784
Article link: Genes Dev


Species referenced: Xenopus laevis
Genes referenced: ctnnbip1 tcf4

References [+] :
Behrens, Functional interaction of beta-catenin with the transcription factor LEF-1. 1996, Pubmed, Xenbase