XB-ART-10714
Yi Chuan Xue Bao
2000 Jan 01;273:195-201.
Show Gene links
Show Anatomy links
[The expression of arrhythmic related genes on Xenopus oocytes for evaluation of class III antiarrhythmic drugs from ocean active material].
???displayArticle.abstract???
By techniques of gene clone, microinjection and patch-clamp, human arrhythmic related gene Kv1.5 and Kv4.2 are translated mRNA, and injected into Xenopus Oocytes, respectively. A pure and single K+ current of ultrarapid delayed rectifier K+ current (Ikur) or transient outward K+ current (Ito) is respectively expressed on Xenopus Oocytes. This is a modern pharmacological model for evaluation class III antiarrhythmic drugs, overcomes many defects such as lacking human fresh cardiac muscle cells as material and co-expression of many currents on cell membrane. A new compound A1998 from Ocean material is evaluated in this model for class III antiarrhythmic functions.
???displayArticle.pubmedLink??? 10887690
Species referenced: Xenopus
Genes referenced: kcna5 kcnd2