Chem Biol Interact 2005 Dec 15;157-158:211-8. doi: 10.1016/j.cbi.2005.10.032.

A peptide derived from acetylcholinesterase is a pivotal signalling molecule in neurodegeneration.

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It is now widely accepted that acetylcholinesterase (AChE) also displays non-cholinergic functions, completely independent of cholinergic transmission. Indeed, AChE has been implicated in a variety of trophic and toxic actions in a range of different systems. However, it is still uncertain what part of the AChE molecule may be responsible for these actions, and indeed via what receptor. Recent work has identified a peptide towards the C-terminus of the AChE molecule that appears to have very similar effects to non-cholinergic AChE itself. This action is to enhance calcium entry, in acute and chronic preparations across a trophic-toxic spectrum, depending on concentration applied and/or duration of exposure.

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Species referenced: Xenopus
Genes referenced: ache