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XB-ART-10737
Mol Cell February 1, 2000; 5 (2): 217-29.

Xenopus embryonic E2F is required for the formation of ventral and posterior cell fates during early embryogenesis.



Abstract
Using an expression cloning approach, we have unveiled a novel function for the transcription factor E2F. We demonstrate that Xenopus E2F (xE2F) is required for patterning of the Xenopus embryonic axis. Overexpression of xE2F in embryos induces ectopic expression of ventral and posterior markers, including selected members of the Hox genes, and suppresses the development of dorsoanterior structures. Loss of xE2F function in embryos leads to the elimination of ventral and posterior structures. These observations suggest that xE2F acts as an important regulator of region-specific gene expression and in the formation of the embryonic axis. This study provides evidence for an additional embryonic function for E2F, independent of its well-documented role in cell cycle regulation, and suggests a novel mechanism of region-specific gene expression during vertebrate embryogenesis.

PubMed ID: 10882064
Article link: Mol Cell
Grant support: [+]
Genes referenced: bmp4 chrd.1 e2f3 e2f6 egr2 evx1 hoxb4 hoxb7 hoxb9 ncam1 odc1 otx2 tbxt wnt8a


Article Images: [+] show captions


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