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Genes Dev June 1, 2000; 14 (11): 1313-8.

Dll4, a novel Notch ligand expressed in arterial endothelium.

Shutter JR , Scully S , Fan W , Richards WG , Kitajewski J , Deblandre GA , Kintner CR , Stark KL .

We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective expression pattern of Dll4 within the vascular endothelium. The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology.

PubMed ID: 10837024
PMC ID: PMC316657
Article link: Genes Dev
Grant support: [+]
Genes referenced: dll1 dll4 egf hes5.1 hes5.2 nog notch1 notch4 notch4.2 tubb2b

Article Images: [+] show captions
References [+] :
Artavanis-Tsakonas, Notch signaling: cell fate control and signal integration in development. 1999, Pubmed

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