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Dev Growth Differ April 1, 2000; 42 (2): 87-93.

Cloning a novel developmental regulating gene, Xotx5: its potential role in anterior formation in Xenopus laevis.

Kuroda H , Hayata T , Eisaki A , Asashima M .

The vertebrate Otx gene family is related to otd, a gene contributing to head development in Drosophila. In Xenopus, Xotx1, Xotx2, and Xotx4 have already been isolated and analyzed. Here the cloning, developmental expression and functions of the additional Otx Xenopus gene, Xotx5 are reported. This latter gene shows a greater degree of homology to Xotx2 than Xotx1 and Xotx4. Xotx5 was initially expressed in Spemann''s organizer and later in the anterior region. Ectopic expression of Xotx5 had similar effects to other Xotx genes in impairing trunk and tail development, and especially similar effects to Xotx2 in causing secondary cement glands. Taken together, these findings suggest that Xotx5 stimulates the formation of the anterior regions and represses the formation of posterior structures similar to Xotx2.

PubMed ID: 10830431
Article link: Dev Growth Differ

Species referenced: Xenopus laevis
Genes referenced: ag1 crx inhba muc2 otx1 otx2

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