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XB-ART-11247
Development May 1, 2000; 127 (9): 1981-90.

The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning.

Sumanas S , Strege P , Heasman J , Ekker SC .


Abstract
We have isolated one member of the frizzled family of wnt receptors from Xenopus (Xfz7) to study the role of cell-cell communication in the establishment of the vertebrate axis. We demonstrate that this maternally encoded protein specifically synergizes with wnt proteins in ectopic axis induction. Embryos derived from oocytes depleted of maternal Xfz7 RNA by antisense oligonucleotide injection are deficient in dorsoanterior structures. Xfz7-depleted embryos are deficient in dorsal but not ventral mesoderm due to the reduced expression of the wnt target genes siamois, Xnr3 and goosecoid. These signaling defects can be restored by the addition of beta-catenin but not Xwnt8b. Xfz7 thus functions upstream of the known GSK-3/axin/beta-catenin intracellular signaling complex in vertebrate dorsoventral mesoderm specification.

PubMed ID: 10751186
Article link: Development
Grant support: [+]
Genes referenced: fzd7 gsc gsk3b nodal3.1 nodal3.2 sia1 wnt11 wnt5a wnt8b


Article Images: [+] show captions


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