Takabatake Y et al. (2000), Conserved and divergent expression of T-box gen...

XB-ART-11377

Mech Dev 2000 Mar 01;911-2:433-7. doi: 10.1016/s0925-4773(99)00329-9.

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Conserved and divergent expression of T-box genes Tbx2-Tbx5 in Xenopus.

Takabatake Y , Takabatake T , Takeshima K .

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We report here the identification of four members of T-box family genes, Xltbx2-Xltbx5, in Xenopus. Two of them are probable pseudovariant genes of XTbx5 and ET, a putative Xenopus ortholog of Tbx3. We compared their expression patterns in both embryos and limbs. In embryos, expression of Xltbx2 and Xltbx3 showed novel diversities, such as Xltbx2 in the neural crest cells and Xltbx3 in the ventral spinal cord, together with mutual similarities in the following regions: dorsal retina, proctoderm, lateral line organ, cement gland and cranial ganglia. The patterns in limbs were highly conserved with mouse and chick orthologs, including the limb-type specific expression of Xltbx4 and Xltbx5. In addition, RT-PCR analysis showed that they are expressed weakly even in adult limbs as previously reported in the newt.

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Species referenced: Xenopus
Genes referenced: tbx2 tbx3 tbx4 tbx5

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	Fig. 3. Expressions of Xltbx2 (A–E) and Xltbx3 (F–H) in embryos. (A) Dorsal view of an embryo at stage 14. (B) Lateral view of an embryo at stage 23. (C) Dorsal view of a pigmented embryo at stage 23. (D,H) Lateral views of embryos at stage 28 (cleared in benzyl benzoate). (E,F) Lateral views of facial regions of embryos at stage 31 (cleared in benzyl benzoate). (G) Transverse sections through spinal cord, notochord and midgut at stage 28. Abbreviations: ba, branchial arches; cg, cement gland; crg, cranial ganglia; fn, frontonasal process; lo, lateral line organ; no, notochord; op, otic placode; ov, otic vesicle; pd, proctodeum; pg, pineal gland; vsc, ventral spinal cord.
	Fig. 4. Expression of Xltbx2 (A–C), Xltbx3 (D–F), Xltbx4 (G–J) and Xltbx5 (K,L) in developing left fore- (J,K) and hind-(A–I,L) limbs. All are dorsal views with anterior to the bottom at stages 50 (G), 51 (A,D), 53 (B,E), 54 (H,J-L), 56 (I) and 56 (C,F).
	tbx2 (T-box 2) gene expression in Xenopus tropicalis, NF stage 14 embryo, assayed via in situ hybridization, latero-dorsal view, anterior right.
	tbx2 (T-box 2) gene expression in Xenopus laevis, NF stage 23 embryo, assayed via in situ hybridization, lateral view, anterior right, dorsal up.
	tbx2 (T-box 2) gene expression in Xenopus laevis, NF stage 23 embryo, assayed via in situ hybridization, dorsal view, anterior right, dorsal up.
	tbx2 (T-box 2) gene expression in Xenopus laevis, NF stage 28 embryo, assayed via in situ hybridization, lateral view, anterior right, dorsal up.
	tbx2 (T-box 2) gene expression in Xenopus laevis, NF stage 31 embryo, assayed via in situ hybridization, lateral view, head region only, anterior right, dorsal up.
	tbx3 (T-box 3) gene expression in Xenopus laevis, NF stage 28 embryo, assayed via in situ hybridization, lateral view, anterior right.
	tbx3 (T-box 3) gene expression in Xenopus laevis, NF stage 28 embryo, assayed via in situ hybridization, transverse section through trunk region, dorsal up.
	tbx3 (T-box 3) gene expression in Xenopus laevis, NF stage 31 embryo, assayed via in situ hybridization, lateral view, head region only, anterior right, dorsal up.
	tbx2 (T-box 2) gene expression in Xenopus laevis, NF stage 56 embryo, assayed via in situ hybridization, lateral view, hind limb.
	tbx3 (T-box 3) gene expression in Xenopus laevis, NF stage 56 embryo, assayed via in situ hybridization, lateral view, hind limb.
	tbx4 (T-box 4) gene expression in Xenopus laevis, NF stage 56 embryo, assayed via in situ hybridization, lateral view, hind limb.
	tbx5 (T-box 5) gene expression in Xenopus laevis, NF stage 56 embryo, assayed via in situ hybridization, lateral view, forelimb.