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XB-ART-11377
Mech Dev March 1, 2000; 91 (1-2): 433-7.

Conserved and divergent expression of T-box genes Tbx2-Tbx5 in Xenopus.

Takabatake Y , Takabatake T , Takeshima K .


Abstract
We report here the identification of four members of T-box family genes, Xltbx2-Xltbx5, in Xenopus. Two of them are probable pseudovariant genes of XTbx5 and ET, a putative Xenopus ortholog of Tbx3. We compared their expression patterns in both embryos and limbs. In embryos, expression of Xltbx2 and Xltbx3 showed novel diversities, such as Xltbx2 in the neural crest cells and Xltbx3 in the ventral spinal cord, together with mutual similarities in the following regions: dorsal retina, proctoderm, lateral line organ, cement gland and cranial ganglia. The patterns in limbs were highly conserved with mouse and chick orthologs, including the limb-type specific expression of Xltbx4 and Xltbx5. In addition, RT-PCR analysis showed that they are expressed weakly even in adult limbs as previously reported in the newt.

PubMed ID: 10704879
Article link: Mech Dev

Genes referenced: tbx2 tbx3 tbx4 tbx5


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