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Mech Dev March 1, 2000; 91 (1-2): 227-35.

Regulation of early expression of Dlx3, a Xenopus anti-neural factor, by beta-catenin signaling.

Beanan MJ , Feledy JA , Sargent TD .

The ectoderm of the pre-gastrula Xenopus embryo has previously been shown to be at least partially patterned along the dorsal-ventral axis. The early expression of the anti-neural homeodomain gene Dlx3 is localized to the ventral ectoderm by a mechanism that occurs prior to gastrulation and is independent of the Spemann organizer. The repression of Dlx3 is mediated by signaling though beta-catenin, but is probably not dependent on the induction of the Xnr3 or chordin genes by beta-catenin. We propose a model in which this early regulation of Dlx3 accounts for the pro-neural bias of dorsal ectoderm.

PubMed ID: 10704847
Article link: Mech Dev

Genes referenced: chrd.1 dlx3 mrc1 nodal3.1 tbxt

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