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XB-ART-12025
Cell 1999 Oct 29;993:301-12. doi: 10.1016/s0092-8674(00)81661-x.
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Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.

Lee MJ , Thangada S , Claffey KP , Ancellin N , Liu CH , Kluk M , Volpi M , Sha'afi RI , Hla T .


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Vascular endothelial cells undergo morphogenesis into capillary networks in response to angiogenic factors. We show here that sphingosine-1-phosphate (SPP), a platelet-derived bioactive lipid, activates the EDG-1 and -3 subtypes of G protein-coupled receptors on endothelial cells to regulate angiogenesis. SPP induces the Gi/mitogen-activated protein kinase/cell survival pathway and the small GTPase Rho- and Raccoupled adherens junction assembly. Both EDG-1-and EDG-3-regulated signaling pathways are required for endothelial cell morphogenesis into capillary-like networks. Indeed, SPP synergized with polypeptide angiogenic growth factors in the formation of mature neovessels in vivo. These data define SPP as a novel regulator of angiogenesis.

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Species referenced: Xenopus laevis
Genes referenced: rho