XB-ART-12097
J Neurosci
November 1, 1999;
19
(21):
9364-73.
Neuralization of the Xenopus embryo by inhibition of p300/ CREB-binding protein function.
Abstract
p300/ CREB-binding protein (CBP) is a transcriptional coactivator for a plethora of transcription factors and plays critical roles in signal transduction pathways. We report that the inhibition of p300/CBP function in the Xenopus embryo abolishes non-neural tissue formation and, strikingly, initiates neural induction and primary neurogenesis in the entire embryo. The observed neuralization is achieved in the absence of anterior or posterior gene expression, suggesting that neural fate activation and anterior patterning may represent distinct molecular events. We further demonstrate that the neuralizing and anteriorizing activities of chordin and noggin are separable properties of these neural inducers. This study reveals that all embryonic cells possess intrinsic neuralizing capability and that p300/CBP function is essential for embryonic germ layer formation and neural fate suppression during vertebrate embryogenesis.
PubMed ID: 10531441
PMC ID: PMC6782909
Article link: J Neurosci
Grant support: [+]
Species referenced: Xenopus
Genes referenced: a2m acvr1 bmp4 celf3 chrd.1 creb1 crebbp ctnnb1 egr2 ep300 gli1 gsc hoxb9 irx2 irx3 krt12.4 mix1 mixer mst1 msx1 ncam1 neurog1 nodal3.1 nodal3.2 nog otx2 sia1 sox17a sox3 tbx2 tbxt tubb2b ventx1.1 wnt8a zic1 zic2 zic3
Article Images: [+] show captions
References [+] :
Aberger,
The Xenopus homologue of hepatocyte growth factor-like protein is specifically expressed in the presumptive neural plate during gastrulation.
1996, Pubmed,
Xenbase
Aberger,
The Xenopus homologue of hepatocyte growth factor-like protein is specifically expressed in the presumptive neural plate during gastrulation.
1996,
Pubmed
,
Xenbase
Akimaru, Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. 1997, Pubmed
Akimaru, Drosophila CBP is required for dorsal-dependent twist gene expression. 1997, Pubmed
Amaya, Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. 1991, Pubmed , Xenbase
Ault, The homeobox gene PV.1 mediates specification of the prospective neural ectoderm in Xenopus embryos. 1998, Pubmed , Xenbase
Bellefroid, Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification. 1998, Pubmed , Xenbase
Bourguignon, XBF-1, a winged helix transcription factor with dual activity, has a role in positioning neurogenesis in Xenopus competent ectoderm. 1999, Pubmed , Xenbase
Brannon, A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. 1997, Pubmed , Xenbase
Brewster, Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. 1998, Pubmed , Xenbase
Cavallo, Drosophila Tcf and Groucho interact to repress Wingless signalling activity. 1998, Pubmed
Chakravarti, A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. 1999, Pubmed
Chang, A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis. 1997, Pubmed , Xenbase
Chitnis, Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. 1995, Pubmed , Xenbase
Cho, Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. 1992, Pubmed , Xenbase
Christian, Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus. 1993, Pubmed , Xenbase
Chrivia, Phosphorylated CREB binds specifically to the nuclear protein CBP. 1993, Pubmed
Darras, Animal and vegetal pole cells of early Xenopus embryos respond differently to maternal dorsal determinants: implications for the patterning of the organiser. 1997, Pubmed , Xenbase
Eckner, p300 and CBP as transcriptional regulators and targets of oncogenic events. 1997, Pubmed
Eckner, Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. 1994, Pubmed
Fagotto, Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/beta-catenin signaling pathway, but not by Vg1, Activin or Noggin. 1997, Pubmed , Xenbase
Feng, The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. 1998, Pubmed
Fujii, Molecular cloning and expression of Xenopus p300/CBP. 1999, Pubmed , Xenbase
Gerhart, Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development. 1990, Pubmed , Xenbase
Goldman, The multifunctional role of the co-activator CBP in transcriptional regulation. 1997, Pubmed
Gupta, Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus. 1998, Pubmed , Xenbase
Gómez-Skarmeta, Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate. 1998, Pubmed , Xenbase
Hamamori, Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. 1999, Pubmed
Harland, In situ hybridization: an improved whole-mount method for Xenopus embryos. 1992, Pubmed , Xenbase
Harland, Formation and function of Spemann's organizer. 1998, Pubmed
Harlow, Association of adenovirus early-region 1A proteins with cellular polypeptides. 1987, Pubmed
Hartenstein, Early neurogenesis in Xenopus: the spatio-temporal pattern of proliferation and cell lineages in the embryonic spinal cord. 1990, Pubmed , Xenbase
He, Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. 1995, Pubmed , Xenbase
Heasman, Patterning the Xenopus blastula. 1997, Pubmed , Xenbase
Hemmati-Brivanlou, A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. 1992, Pubmed , Xenbase
Hemmati-Brivanlou, Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. 1994, Pubmed , Xenbase
Hemmati-Brivanlou, Vertebrate neural induction. 1997, Pubmed , Xenbase
Henry, TGF-beta signals and a pattern in Xenopus laevis endodermal development. 1996, Pubmed , Xenbase
Henry, Mixer, a homeobox gene required for endoderm development. 1998, Pubmed , Xenbase
Hudson, Xsox17alpha and -beta mediate endoderm formation in Xenopus. 1997, Pubmed , Xenbase
Janknecht, Transcription. A growing coactivator network. 1996, Pubmed
Janknecht, TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. 1998, Pubmed
Joseph, Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos. 1998, Pubmed , Xenbase
Kannabiran, The adenovirus E1A 12S product displays functional redundancy in activating the human proliferating cell nuclear antigen promoter. 1993, Pubmed
Kessler, Vertebrate embryonic induction: mesodermal and neural patterning. 1994, Pubmed , Xenbase
Kintner, Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. 1987, Pubmed , Xenbase
Kuo, Opl: a zinc finger protein that regulates neural determination and patterning in Xenopus. 1998, Pubmed , Xenbase
LaBonne, Mesoderm induction by activin requires FGF-mediated intracellular signals. 1994, Pubmed , Xenbase
Lamb, Neural induction by the secreted polypeptide noggin. 1993, Pubmed , Xenbase
Lee, Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. 1997, Pubmed , Xenbase
Lee, Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300. 1996, Pubmed
Ma, Identification of neurogenin, a vertebrate neuronal determination gene. 1996, Pubmed , Xenbase
Mariani, XBF-2 is a transcriptional repressor that converts ectoderm into neural tissue. 1999, Pubmed , Xenbase
Mayor, Induction of the prospective neural crest of Xenopus. 1995, Pubmed , Xenbase
McKendry, LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter. 1998, Pubmed , Xenbase
Mead, Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. 1998, Pubmed , Xenbase
Mizuseki, Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction. 1998, Pubmed , Xenbase
Mizuseki, SoxD: an essential mediator of induction of anterior neural tissues in Xenopus embryos. 1998, Pubmed , Xenbase
Moran, Interaction of adenoviral proteins with pRB and p53. 1993, Pubmed
Nakashima, Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. 1999, Pubmed
Nakata, Xenopus Zic3, a primary regulator both in neural and neural crest development. 1997, Pubmed , Xenbase
Nevins, E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. 1992, Pubmed
Papalopulu, A posteriorising factor, retinoic acid, reveals that anteroposterior patterning controls the timing of neuronal differentiation in Xenopus neuroectoderm. 1997, Pubmed , Xenbase
Penzel, Characterization and early embryonic expression of a neural specific transcription factor xSOX3 in Xenopus laevis. 1998, Pubmed , Xenbase
Pouponnot, Physical and functional interaction of SMADs and p300/CBP. 1998, Pubmed
Roose, The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. 1998, Pubmed , Xenbase
Ruiz i Altaba, Involvement of Livertine, a hepatocyte growth factor family member, in neural morphogenesis. 1997, Pubmed , Xenbase
Sasai, Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. 1995, Pubmed , Xenbase
Sasai, Identifying the missing links: genes that connect neural induction and primary neurogenesis in vertebrate embryos. 1998, Pubmed
Sasai, Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. 1997, Pubmed , Xenbase
Sasai, Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. 1995, Pubmed , Xenbase
Sasai, Ectodermal patterning in vertebrate embryos. 1997, Pubmed , Xenbase
Saxén, Neural induction. 1990, Pubmed
Shen, TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. 1999, Pubmed
Shi, A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. 1998, Pubmed
Shiama, The p300/CBP family: integrating signals with transcription factors and chromatin. 2012, Pubmed
Smith, A nodal-related gene defines a physical and functional domain within the Spemann organizer. 1995, Pubmed , Xenbase
Smith, Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. 1991, Pubmed , Xenbase
Smith, Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. 1992, Pubmed , Xenbase
Streit, Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo. 1998, Pubmed
Streit, Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2. 1997, Pubmed , Xenbase
Suzuki, Regulation of epidermal induction by BMP2 and BMP7 signaling. 1997, Pubmed , Xenbase
Suzuki, Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4. 1997, Pubmed , Xenbase
Topper, CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells. 1998, Pubmed
Turner, Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. 1994, Pubmed , Xenbase
Wade, Histone acetyltransferases in control. 1997, Pubmed
Waltzer, A function of CBP as a transcriptional co-activator during Dpp signalling. 1999, Pubmed
Waltzer, Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. 1998, Pubmed
Wang, Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth. 1993, Pubmed
Watabe, Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. 1996, Pubmed , Xenbase
Wilson, Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. 1994, Pubmed , Xenbase
Wilson, Induction of epidermis and inhibition of neural fate by Bmp-4. 1995, Pubmed , Xenbase
Wilson, Vertebrate neural induction: inducers, inhibitors, and a new synthesis. 1997, Pubmed , Xenbase
Yao, Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. 1998, Pubmed
Yee, Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides. 1985, Pubmed
Zeng, The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. 1997, Pubmed , Xenbase
Akimaru, Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. 1997, Pubmed
Akimaru, Drosophila CBP is required for dorsal-dependent twist gene expression. 1997, Pubmed
Amaya, Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. 1991, Pubmed , Xenbase
Ault, The homeobox gene PV.1 mediates specification of the prospective neural ectoderm in Xenopus embryos. 1998, Pubmed , Xenbase
Bellefroid, Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification. 1998, Pubmed , Xenbase
Bourguignon, XBF-1, a winged helix transcription factor with dual activity, has a role in positioning neurogenesis in Xenopus competent ectoderm. 1999, Pubmed , Xenbase
Brannon, A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. 1997, Pubmed , Xenbase
Brewster, Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. 1998, Pubmed , Xenbase
Cavallo, Drosophila Tcf and Groucho interact to repress Wingless signalling activity. 1998, Pubmed
Chakravarti, A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. 1999, Pubmed
Chang, A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis. 1997, Pubmed , Xenbase
Chitnis, Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. 1995, Pubmed , Xenbase
Cho, Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. 1992, Pubmed , Xenbase
Christian, Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus. 1993, Pubmed , Xenbase
Chrivia, Phosphorylated CREB binds specifically to the nuclear protein CBP. 1993, Pubmed
Darras, Animal and vegetal pole cells of early Xenopus embryos respond differently to maternal dorsal determinants: implications for the patterning of the organiser. 1997, Pubmed , Xenbase
Eckner, p300 and CBP as transcriptional regulators and targets of oncogenic events. 1997, Pubmed
Eckner, Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. 1994, Pubmed
Fagotto, Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/beta-catenin signaling pathway, but not by Vg1, Activin or Noggin. 1997, Pubmed , Xenbase
Feng, The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. 1998, Pubmed
Fujii, Molecular cloning and expression of Xenopus p300/CBP. 1999, Pubmed , Xenbase
Gerhart, Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development. 1990, Pubmed , Xenbase
Goldman, The multifunctional role of the co-activator CBP in transcriptional regulation. 1997, Pubmed
Gupta, Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus. 1998, Pubmed , Xenbase
Gómez-Skarmeta, Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate. 1998, Pubmed , Xenbase
Hamamori, Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. 1999, Pubmed
Harland, In situ hybridization: an improved whole-mount method for Xenopus embryos. 1992, Pubmed , Xenbase
Harland, Formation and function of Spemann's organizer. 1998, Pubmed
Harlow, Association of adenovirus early-region 1A proteins with cellular polypeptides. 1987, Pubmed
Hartenstein, Early neurogenesis in Xenopus: the spatio-temporal pattern of proliferation and cell lineages in the embryonic spinal cord. 1990, Pubmed , Xenbase
He, Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. 1995, Pubmed , Xenbase
Heasman, Patterning the Xenopus blastula. 1997, Pubmed , Xenbase
Hemmati-Brivanlou, A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. 1992, Pubmed , Xenbase
Hemmati-Brivanlou, Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. 1994, Pubmed , Xenbase
Hemmati-Brivanlou, Vertebrate neural induction. 1997, Pubmed , Xenbase
Henry, TGF-beta signals and a pattern in Xenopus laevis endodermal development. 1996, Pubmed , Xenbase
Henry, Mixer, a homeobox gene required for endoderm development. 1998, Pubmed , Xenbase
Hudson, Xsox17alpha and -beta mediate endoderm formation in Xenopus. 1997, Pubmed , Xenbase
Janknecht, Transcription. A growing coactivator network. 1996, Pubmed
Janknecht, TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. 1998, Pubmed
Joseph, Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos. 1998, Pubmed , Xenbase
Kannabiran, The adenovirus E1A 12S product displays functional redundancy in activating the human proliferating cell nuclear antigen promoter. 1993, Pubmed
Kessler, Vertebrate embryonic induction: mesodermal and neural patterning. 1994, Pubmed , Xenbase
Kintner, Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. 1987, Pubmed , Xenbase
Kuo, Opl: a zinc finger protein that regulates neural determination and patterning in Xenopus. 1998, Pubmed , Xenbase
LaBonne, Mesoderm induction by activin requires FGF-mediated intracellular signals. 1994, Pubmed , Xenbase
Lamb, Neural induction by the secreted polypeptide noggin. 1993, Pubmed , Xenbase
Lee, Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. 1997, Pubmed , Xenbase
Lee, Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300. 1996, Pubmed
Ma, Identification of neurogenin, a vertebrate neuronal determination gene. 1996, Pubmed , Xenbase
Mariani, XBF-2 is a transcriptional repressor that converts ectoderm into neural tissue. 1999, Pubmed , Xenbase
Mayor, Induction of the prospective neural crest of Xenopus. 1995, Pubmed , Xenbase
McKendry, LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter. 1998, Pubmed , Xenbase
Mead, Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. 1998, Pubmed , Xenbase
Mizuseki, Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction. 1998, Pubmed , Xenbase
Mizuseki, SoxD: an essential mediator of induction of anterior neural tissues in Xenopus embryos. 1998, Pubmed , Xenbase
Moran, Interaction of adenoviral proteins with pRB and p53. 1993, Pubmed
Nakashima, Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. 1999, Pubmed
Nakata, Xenopus Zic3, a primary regulator both in neural and neural crest development. 1997, Pubmed , Xenbase
Nevins, E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. 1992, Pubmed
Papalopulu, A posteriorising factor, retinoic acid, reveals that anteroposterior patterning controls the timing of neuronal differentiation in Xenopus neuroectoderm. 1997, Pubmed , Xenbase
Penzel, Characterization and early embryonic expression of a neural specific transcription factor xSOX3 in Xenopus laevis. 1998, Pubmed , Xenbase
Pouponnot, Physical and functional interaction of SMADs and p300/CBP. 1998, Pubmed
Roose, The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. 1998, Pubmed , Xenbase
Ruiz i Altaba, Involvement of Livertine, a hepatocyte growth factor family member, in neural morphogenesis. 1997, Pubmed , Xenbase
Sasai, Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. 1995, Pubmed , Xenbase
Sasai, Identifying the missing links: genes that connect neural induction and primary neurogenesis in vertebrate embryos. 1998, Pubmed
Sasai, Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. 1997, Pubmed , Xenbase
Sasai, Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. 1995, Pubmed , Xenbase
Sasai, Ectodermal patterning in vertebrate embryos. 1997, Pubmed , Xenbase
Saxén, Neural induction. 1990, Pubmed
Shen, TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. 1999, Pubmed
Shi, A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. 1998, Pubmed
Shiama, The p300/CBP family: integrating signals with transcription factors and chromatin. 2012, Pubmed
Smith, A nodal-related gene defines a physical and functional domain within the Spemann organizer. 1995, Pubmed , Xenbase
Smith, Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. 1991, Pubmed , Xenbase
Smith, Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. 1992, Pubmed , Xenbase
Streit, Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo. 1998, Pubmed
Streit, Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2. 1997, Pubmed , Xenbase
Suzuki, Regulation of epidermal induction by BMP2 and BMP7 signaling. 1997, Pubmed , Xenbase
Suzuki, Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4. 1997, Pubmed , Xenbase
Topper, CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells. 1998, Pubmed
Turner, Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. 1994, Pubmed , Xenbase
Wade, Histone acetyltransferases in control. 1997, Pubmed
Waltzer, A function of CBP as a transcriptional co-activator during Dpp signalling. 1999, Pubmed
Waltzer, Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. 1998, Pubmed
Wang, Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth. 1993, Pubmed
Watabe, Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. 1996, Pubmed , Xenbase
Wilson, Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. 1994, Pubmed , Xenbase
Wilson, Induction of epidermis and inhibition of neural fate by Bmp-4. 1995, Pubmed , Xenbase
Wilson, Vertebrate neural induction: inducers, inhibitors, and a new synthesis. 1997, Pubmed , Xenbase
Yao, Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. 1998, Pubmed
Yee, Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides. 1985, Pubmed
Zeng, The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. 1997, Pubmed , Xenbase