Identification of novel F-box proteins in Xenopus laevis.
PubMed ID: 10531041
Article link: Curr Biol.
Grant support: GM07365 NIGMS NIH HHS , GM54811 NIGMS NIH HHS
Genes referenced: fbxl14 fbxl5 fbxo28 fbxo43 mtus1 skp1
Article Images: [+] show captions
|Figure 1. A family of F-box proteins in Xenopus laevis, isolated through their ability to bind Skp1. (a) Alignment of F-box domain sequences. The F-box domains from Fbl5, Fbl13, Fbx26, Fbx27 and Fbx28 were aligned using CLUSTAL V. The consensus sequence is shown above. Red, most highly conserved; blue, highly conserved; underline, similar. Dots indicate gaps. The clones were isolated the following number of times: Fbl5 (3), Fbl13 (1), Fbx26 (395), Fbx27 (5), Fbx28 (1). (b) Schematic representation of the domain structures of X. laevis F-box proteins.|
|Figure 2. Phylogenetic tree showing evolutionary relationships within the subfamily of F-box proteins characterized by leucine-rich repeats. Ce, Caenorhabditis elegans; Hs, Homo sapiens; Mm, Mus musculus; Sc, Saccharomyces cerevisiae; Sp, Schizosaccharomyces pombe; Xl, X. laevis.|