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Differentiation September 1, 2005; 73 (7): 323-9.

Frodo proteins: modulators of Wnt signaling in vertebrate development.

Brott BK , Sokol SY .

The Frodo/dapper (Frd) proteins are recently discovered signaling adaptors, which functionally and physically interact with Wnt and Nodal signaling pathways during vertebrate development. The Frd1 and Frd2 genes are expressed in dynamic patterns in early embryos, frequently in cells undergoing epithelial-mesenchymal transition. The Frd proteins function in multiple developmental processes, including mesoderm and neural tissue specification, early morphogenetic cell movements, and organogenesis. Loss-of-function studies using morpholino antisense oligonucleotides demonstrate that the Frd proteins regulate Wnt signal transduction in a context-dependent manner and may be involved in Nodal signaling. The identification of Frd-associated factors and cellular targets of the Frd proteins should shed light on the molecular mechanisms underlying Frd functions in embryonic development and in cancer.

PubMed ID: 16219036
Article link: Differentiation

Genes referenced: cer1 chrd.1 ctnnb1 dact1 dbf4 dvl2 fzd8 gsc mapk8 nodal nodal3.1 nrp1 rac1 tcf7l1 wnt1

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