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Semin Cell Dev Biol February 1, 1999; 10 (1): 85-91.

GATA transcription factors and cardiac development.

Charron F , Nemer M .

Three members of the GATA family of transcription factors, GATA-4, -5, and -6, are expressed in the developing heart. One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions. The mechanisms underlying GATA factor specificity are not fully understood but may involve interaction with other tissue-restricted or ubiquitous co-factors. Thus, combinatorial interaction among GATA factors or between GATA factors and other co-factors may differentially control various stages of cardiogenesis.

PubMed ID: 10355032
Article link: Semin Cell Dev Biol

Species referenced: Xenopus
Genes referenced: gata4 gata5