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XB-ART-13222
Neuron March 1, 1999; 22 (3): 537-48.

A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels.

Zerangue N , Schwappach B , Jan YN , Jan LY .


Abstract
Proper ion channel function often requires specific combinations of pore-forming alpha and regulatory beta subunits, but little is known about the mechanisms that regulate the surface expression of different channel combinations. Our studies of ATP-sensitive K+ channel (K(ATP)) trafficking reveal an essential quality control function for a trafficking motif present in each of the alpha (Kir6.1/2) and beta (SUR1) subunits of the K(ATP) complex. We show that this novel motif for endoplasmic reticulum (ER) retention/retrieval is required at multiple stages of K(ATP) assembly to restrict surface expression to fully assembled and correctly regulated octameric channels. We conclude that exposure of a three amino acid motif (RKR) can explain how assembly of an ion channel complex is coupled to intracellular trafficking.

PubMed ID: 10197533
Article link: Neuron

Genes referenced: kcnj11



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