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Nat Neurosci. March 1, 1999; 2 (3): 234-40.

Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems.

Alagarsamy S , Marino MJ , Rouse ST , Gereau RW , Heinemann SF , Conn PJ .

The metabotropic glutamate receptor, mGluR5, has a critical role in induction of NMDA-receptor-dependent forms of synaptic plasticity and excitotoxicity. This is likely mediated by a reciprocal positive-feedback interaction between these two glutamate receptor subtypes in which activation of mGluR5 potentiates NMDA receptor currents and NMDA receptor activation potentiates mGluR5-mediated responses. We have investigated the mechanism by which NMDA receptor activation modulates mGluR5 function and find evidence that this response is mediated by activation of a protein phosphatase and a resultant dephosphorylation of protein kinase C phosphorylation sites on mGluR5. This form of neuromodulation may be important in a number of normal and pathological processes that involve activation of the NMDA receptor.

PubMed ID: 10195215
Article link: Nat Neurosci.

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