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J Bioenerg Biomembr
1998 Aug 01;304:313-8. doi: 10.1023/a:1021981420839.
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Molecular characterization of a novel family of low voltage-activated, T-type, calcium channels.
Perez-Reyes E
.
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Low voltage-activated, T-type, calcium channels are thought to be involved in pacemaker activity, low threshold Ca2+ spikes, neuronal oscillations and resonance, and rebound burst firing. Mutations in T-type channel genes may be a contributing factor to neurological and cardiovascular disorders, such as epilepsy, arrhythmia, and hypertension. Due to the lack of selective blockers, little is known about their structure or molecular biology. This review discusses our recent findings on the cloning, chromosomal localization, and functional expression, of two novel channels, alpha1G and alpha1H. The biophysical properties of these cloned channels (distinctive voltage dependence, kinetics, and single channel conductance) demonstrates that these channels are members of the T-type Ca2+ channel family.
ANDERSEN,
THE VENTRO-BASAL COMPLEX OF THE THALAMUS: TYPES OF CELLS, THEIR RESPONSES AND THEIR FUNCTIONAL ORGANIZATION.
1964, Pubmed
ANDERSEN,
THE VENTRO-BASAL COMPLEX OF THE THALAMUS: TYPES OF CELLS, THEIR RESPONSES AND THEIR FUNCTIONAL ORGANIZATION.
1964,
Pubmed
Akaike,
Low-voltage-activated calcium current in rat aorta smooth muscle cells in primary culture.
1989,
Pubmed
Altschul,
Basic local alignment search tool.
1990,
Pubmed
Arnoult,
Activation of mouse sperm T-type Ca2+ channels by adhesion to the egg zona pellucida.
1996,
Pubmed
Bean,
Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.
1985,
Pubmed
Bezprozvanny,
Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967).
1995,
Pubmed
,
Xenbase
Bossu,
Depolarization elicits two distinct calcium currents in vertebrate sensory neurones.
1985,
Pubmed
Bourinet,
The alpha 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels.
1996,
Pubmed
,
Xenbase
Burgess,
Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse.
1997,
Pubmed
Carbone,
A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones.
,
Pubmed
Castellano,
Cloning and expression of a neuronal calcium channel beta subunit.
1993,
Pubmed
,
Xenbase
Chen,
Mechanism of gating of T-type calcium channels.
1990,
Pubmed
Cohen,
Ca channels in adrenal glomerulosa cells: K+ and angiotensin II increase T-type Ca channel current.
1988,
Pubmed
Coulter,
Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction.
1990,
Pubmed
Coulter,
Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current.
1989,
Pubmed
Cribbs,
Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family.
1998,
Pubmed
Crunelli,
A T-type Ca2+ current underlies low-threshold Ca2+ potentials in cells of the cat and rat lateral geniculate nucleus.
1989,
Pubmed
Doyle,
Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice.
1997,
Pubmed
Enyeart,
T-type Ca2+ channels are required for adrenocorticotropin-stimulated cortisol production by bovine adrenal zona fasciculata cells.
1993,
Pubmed
Fedulova,
Two types of calcium channels in the somatic membrane of new-born rat dorsal root ganglion neurones.
1985,
Pubmed
Fisher,
Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp.
1997,
Pubmed
Fletcher,
Absence epilepsy in tottering mutant mice is associated with calcium channel defects.
1996,
Pubmed
Hagiwara,
Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells.
1988,
Pubmed
Hernández-Cruz,
Identification of two calcium currents in acutely dissociated neurons from the rat lateral geniculate nucleus.
1989,
Pubmed
Higgins,
CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.
1988,
Pubmed
Huguenard,
Low-threshold calcium currents in central nervous system neurons.
1996,
Pubmed
Jan,
A superfamily of ion channels.
1990,
Pubmed
Kelly,
Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons.
1990,
Pubmed
Ketchum,
A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem.
1995,
Pubmed
,
Xenbase
Lacerda,
T-type and N-type calcium channels of Xenopus oocytes: evidence for specific interactions with beta subunits.
1994,
Pubmed
,
Xenbase
Lambert,
T-type Ca2+ current properties are not modified by Ca2+ channel beta subunit depletion in nodosus ganglion neurons.
1997,
Pubmed
Lennon,
The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression.
1996,
Pubmed
Llinás,
Electrophysiology of mammalian thalamic neurones in vitro.
1982,
Pubmed
Matteson,
Properties of two types of calcium channels in clonal pituitary cells.
1986,
Pubmed
Meier,
The neuropathy of teetering, a neurological mutation in the mouse.
1967,
Pubmed
Montgomery,
Chromosome 11.
1997,
Pubmed
Nilius,
A novel type of cardiac calcium channel in ventricular cells.
,
Pubmed
Nowycky,
Three types of neuronal calcium channel with different calcium agonist sensitivity.
,
Pubmed
Ophoff,
Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4.
1996,
Pubmed
Perez-Reyes,
Molecular characterization of a neuronal low-voltage-activated T-type calcium channel.
1998,
Pubmed
,
Xenbase
Perez-Reyes,
Molecular biology of calcium channels.
1995,
Pubmed
Pragnell,
Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.
1994,
Pubmed
Randall,
Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels.
1997,
Pubmed
Santi,
A dihydropyridine-sensitive T-type Ca2+ current is the main Ca2+ current carrier in mouse primary spermatocytes.
1996,
Pubmed
Schneider,
Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit.
1994,
Pubmed
,
Xenbase
Sen,
T-type Ca2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts.
1994,
Pubmed
Shuba,
The effect of permeant ions on single calcium channel activation in mouse neuroblastoma cells: ion-channel interaction.
1991,
Pubmed
Singer-Lahat,
Evidence for the existence of RNA of Ca(2+)-channel alpha 2/delta subunit in Xenopus oocytes.
1992,
Pubmed
,
Xenbase
Soares,
Construction and characterization of a normalized cDNA library.
1994,
Pubmed
Soong,
Structure and functional expression of a member of the low voltage-activated calcium channel family.
1993,
Pubmed
Stühmer,
Structural parts involved in activation and inactivation of the sodium channel.
1989,
Pubmed
,
Xenbase
Suzuki,
T-type calcium channels mediate the transition between tonic and phasic firing in thalamic neurons.
1989,
Pubmed
Tanabe,
Primary structure of the receptor for calcium channel blockers from skeletal muscle.
,
Pubmed
Tang,
Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel.
1993,
Pubmed
Tareilus,
A Xenopus oocyte beta subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit.
1997,
Pubmed
,
Xenbase
Todorovic,
Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents.
1998,
Pubmed
Tsakiridou,
Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy.
1995,
Pubmed
Wakamori,
Distinctive functional properties of the neuronal BII (class E) calcium channel.
1994,
Pubmed
,
Xenbase
Williams,
Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.
1994,
Pubmed
,
Xenbase
Yang,
Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels.
1993,
Pubmed
,
Xenbase
de Leon,
Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels.
1995,
Pubmed
