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J Biol Chem. September 8, 2006; 281 (36): 26725-33.

CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces.

Thomas JT , Prakash D , Weih K , Moos M .

CDMP1/GDF5 has not demonstrated biological activity in Xenopus embryos when overexpressed by mRNA injection. We provide biological and biochemical evidence that to become active, the protein requires cleavage by two distinct proteolytic enzymes. We demonstrate a specific overlap in the expression patterns of CDMP1/GDF5 with the proteases required to release the mature peptide at the location of the future articular surface but not in the future joint space. Taken together, these observations provide a plausible mechanism for local action of CDMP1/GDF5 consistent with requirements imposed by current models of pattern formation in the developing limb.

PubMed ID: 16829522
Article link: J Biol Chem.

Genes referenced: bmp2 bmp3 bmp4 bmp5 bmp6 bmp7.1 dspp evx1 furin gdf1 gdf5 hist1h4d inhba mut nodal pcsk5 pcsk6 sftpc tbxt ventx1.2

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