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EMBO J April 1, 1998; 17 (7): 2107-21.

Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA.

Matsumoto K , Wassarman KM , Wolffe AP .

The pathways of synthesis and maturation of pre-messenger RNA in the nucleus have a direct effect on the translational efficiency of mRNA in the cytoplasm. The transcription of intron-less mRNA in vivo directs this mRNA towards translational silencing. The presence of an intron at the 5'' end of the transcript relieves this silencing, whereas an intron at the 3'' end further represses translation. These regulatory events are strongly dependent on the transcription of pre-mRNA in the nucleus. The impact of nuclear history on regulatory events in the cytoplasm provides a novel mechanism for the control of gene expression.

PubMed ID: 9524132
PMC ID: PMC1170555
Article link: EMBO J

References [+] :
Almouzni, Replication-coupled chromatin assembly is required for the repression of basal transcription in vivo. 1993, Pubmed, Xenbase