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XB-ART-15074
Science April 24, 1998; 280 (5363): 596-9.

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.

Behrens J , Jerchow BA , Würtele M , Grimm J , Asbrand C , Wirtz R , Kühl M , Wedlich D , Birchmeier W .


Abstract
Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced beta-catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized beta-catenin. Fragments of APC that contained a conductin-binding domain also blocked beta-catenin degradation. Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation.

PubMed ID: 9554852
Article link: Science


Species referenced: Xenopus laevis
Genes referenced: gsk3b