Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-15119
Curr Opin Cell Biol 1998 Apr 01;102:188-94. doi: 10.1016/s0955-0674(98)80141-5.
Show Gene links Show Anatomy links

Mads and Smads in TGF beta signalling.

Attisano L , Wrana JL .


???displayArticle.abstract???
The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window on an entirely unique signalling pathway that functions to mediate responses to the tumour growth factor beta (TGF beta) superfamily. This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases.

???displayArticle.pubmedLink??? 9561843
???displayArticle.link??? Curr Opin Cell Biol


Species referenced: Xenopus
Genes referenced: dspp tgfb1
GO keywords: regulation of transforming growth factor beta receptor signaling pathway

???displayArticle.disOnts??? cancer