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Biochem Biophys Res Commun March 27, 1998; 244 (3): 763-7.

Identification of phosphorylated proteins associated with the fibroblast growth factor receptor type I during early Xenopus development.

Ryan PJ , Paterno GD , Gillespie LL .

Signaling through the FGF receptor (FGFR) is required for mesoderm induction in Xenopus. Some of the downstream signaling molecules implicated in this developmental process include Ras, Raf and MAP kinase. In a previous report, we demonstrated that PLC gamma 1, Grb-2, SOS and Nck were associated with activated FGFR1s in a signaling complex in Xenopus blastulae. In addition, several unidentified phosphotyrosylproteins were present in the FGFR1 complex. Here we identify three of these proteins as Ras-GAP, the p85 of P13''K and SHP2, while demonstrating that c-Src and She were not associated with the FGFR1. Furthermore, we show that three additional phosphotyrosylproteins from the FGFR1 complex specifically bound to the adaptor molecule Nck.

PubMed ID: 9535739
Article link: Biochem Biophys Res Commun

Species referenced: Xenopus laevis
Genes referenced: arhgef7 fgfr1 mapk1 nck1 plcg1 ptpn11 she src