XB-ART-15416
Curr Biol
1997 Nov 01;711:R698-700. doi: 10.1016/s0960-9822(06)00359-9.
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Development: morphogen gradients and mesodermal patterning.
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Activin has long-range effects in Xenopus development, inducing the mesodermally expressed brachyury gene up to 10 cell diameters from a localised source. Recent experiments show that activin diffuses through tissues to establish a morphogen gradient, and that the long-range effects are a direct result of activin signalling.
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Species referenced: Xenopus
Genes referenced: gsc tbxt tgfbr1 tgfbr2