Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-15433
Neurosci Lett 1997 Dec 19;2392-3:113-6. doi: 10.1016/s0304-3940(97)00908-7.
Show Gene links Show Anatomy links

Overexpression of neurogenin induces ectopic expression of HuC in zebrafish.

Kim CH , Bae YK , Yamanaka Y , Yamashita S , Shimizu T , Fujii R , Park HC , Yeo SY , Huh TL , Hibi M , Hirano T .


???displayArticle.abstract???
Several basic helix-loop-helix (bHLH) transcription factors are known to be involved in vertebrate neurogenesis. To investigate their roles in zebrafish neurogenesis, we isolated cDNAs for homologues of neurogenin and Math(-1)/atonal. The transcription of neurogenin was first detectable in zebrafish nervous system at late gastrulation stage. The expression of zebrafish neurogenin precedes and overlaps that of HuC, one of the earliest neuronal precursor markers. Injection of neurogenin mRNA into early stage zebrafish embryos induced ectopic expression of HuC. These results suggest that neurogenin may participate in the generation of HuC-expressing cells, implying its role in neuronal determination in zebrafish.

???displayArticle.pubmedLink??? 9469669
???displayArticle.link??? Neurosci Lett


Species referenced: Xenopus
Genes referenced: elavl3 neurog1