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XB-ART-15626
Gene December 12, 1997; 203 (2): 183-8.

An interferon regulatory factor-related gene (xIRF-6) is expressed in the posterior mesoderm during the early development of Xenopus laevis.

Hatada S , Kinoshita M , Takahashi S , Nishihara R , Sakumoto H , Fukui A , Noda M , Asashima M .


Abstract
Out of a Xenopus neurula cDNA library, we isolated a clone which encodes a 52.4-kDa protein highly similar to the mouse interferon regulatory factor, IRF-6, whose function is unknown. The mRNA of this gene, named xIRF-6, seems to be maternally transmitted, but its amount rapidly decreases after the tailbud stage. Whole-mount in situ hybridization showed that xIRF-6 mRNA is expressed in the presumptive somitic mesoderm in the late gastrula, and then confined to a segment of posterior somite during the neurula through the tailbud stage. The temporally and spatially limited expression of the xIRF-6 gene product may contribute to the transcriptional regulation of specific genes which are necessary for the development of the posterior somites.

PubMed ID: 9426249
Article link: Gene


Species referenced: Xenopus laevis
Genes referenced: irf2 irf6 myb myf5


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