O'Reilly AM , Neel BG .

R01 CA49152 NCI NIH HHS , R01 CA049152 NCI NIH HHS

Ali, PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation. 1996, Pubmed

Ali, PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation. 1996, Pubmed
Allard, The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. 1996, Pubmed
Amaya, FGF signalling in the early specification of mesoderm in Xenopus. 1993, Pubmed , Xenbase
Amaya, Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. 1991, Pubmed , Xenbase
Aroian, The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. , Pubmed
Arrandale, Insulin signaling in mice expressing reduced levels of Syp. 1996, Pubmed
Barford, Crystal structure of human protein tyrosine phosphatase 1B. 1994, Pubmed
Bennett, Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. 1994, Pubmed
Bennett, Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression. 1996, Pubmed
Bignon, Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function. 1994, Pubmed
Burshtyn, A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1. 1997, Pubmed
Clark, C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. 1992, Pubmed
Cohen, Modular binding domains in signal transduction proteins. 1995, Pubmed
Dechert, Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains. 1994, Pubmed
Dechert, Comparison of the specificity of bacterially expressed cytoplasmic protein-tyrosine phosphatases SHP and SH-PTP2 towards synthetic phosphopeptide substrates. 1995, Pubmed
Deng, Murine FGFR-1 is required for early postimplantation growth and axial organization. 1994, Pubmed , Xenbase
Dominguez, Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos. 1995, Pubmed , Xenbase
Duffy, The torso pathway in Drosophila: lessons on receptor tyrosine kinase signaling and pattern formation. 1994, Pubmed
Duffy, Recent advances in understanding signal transduction pathways in worms and flies. 1996, Pubmed
Eck, Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2. 1996, Pubmed
Feng, Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. 1994, Pubmed
Feng, SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. 1993, Pubmed
Flint, Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases. 1997, Pubmed
Freeman, Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. 1992, Pubmed
Fujioka, A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. 1996, Pubmed
Garton, Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. 1996, Pubmed
Green, Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. 1990, Pubmed , Xenbase
Hausdorff, Different signaling roles of SHPTP2 in insulin-induced GLUT1 expression and GLUT4 translocation. 1995, Pubmed
Herbst, Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. 1996, Pubmed
Holgado-Madruga, A Grb2-associated docking protein in EGF- and insulin-receptor signalling. 1996, Pubmed
Huyer, Direct determination of the sequence recognition requirements of the SH2 domains of SH-PTP2. 1995, Pubmed
Itoh, Heparan sulfate proteoglycans are required for mesoderm formation in Xenopus embryos. 1994, Pubmed , Xenbase
Kharitonenkov, A family of proteins that inhibit signalling through tyrosine kinase receptors. 1997, Pubmed
Klein, Hormonal regulation of embryogenesis: the formation of mesoderm in Xenopus laevis. 1994, Pubmed , Xenbase
Kouhara, A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. 1997, Pubmed
Kuhné, The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. 1993, Pubmed
Lechleider, Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2. 1993, Pubmed
Lechleider, Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. 1993, Pubmed
Lee, Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. 1994, Pubmed
Li, A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. 1994, Pubmed
Liu, Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2. 1997, Pubmed
Luetteke, The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. 1994, Pubmed
Marengère, Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. 1996, Pubmed
Marshall, MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. 1994, Pubmed
Mauro, 'Zip codes' direct intracellular protein tyrosine phosphatases to the correct cellular 'address'. 1994, Pubmed
McCormick, Activators and effectors of ras p21 proteins. 1994, Pubmed
Neel, Protein tyrosine phosphatases in signal transduction. 1997, Pubmed
Neel, Structure and function of SH2-domain containing tyrosine phosphatases. 1993, Pubmed
Newport, A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. 1982, Pubmed , Xenbase
Nieuwkoop, The formation of the mesoderm in urodelean amphibians : I. Induction by the endoderm. 1969, Pubmed
Noguchi, Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. 1994, Pubmed
Noguchi, Characterization of a 115-kDa protein that binds to SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in Chinese hamster ovary cells. 1996, Pubmed
Olivier, A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. 1993, Pubmed
Pei, Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains. 1994, Pubmed
Pei, Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1. 1996, Pubmed
Pei, Overexpression, purification, and characterization of SHPTP1, a Src homology 2-containing protein-tyrosine-phosphatase. 1993, Pubmed
Perkins, The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. 1996, Pubmed
Perkins, corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. 1992, Pubmed
Perrimon, Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila. 1994, Pubmed
Perrimon, There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor. 1997, Pubmed
Pluskey, Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. 1995, Pubmed
Plutzky, Isolation of a src homology 2-containing tyrosine phosphatase. 1992, Pubmed
Pregel, Regulation of protein tyrosine phosphatase 1C: opposing effects of the two src homology 2 domains. 1995, Pubmed
Roche, Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways. 1996, Pubmed
Rottapel, The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. 1991, Pubmed
Saxton, Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. 1997, Pubmed
Seger, The MAPK signaling cascade. 1995, Pubmed
Simon, Signal transduction during the development of the Drosophila R7 photoreceptor. 1994, Pubmed
Songyang, Use of an oriented peptide library to determine the optimal substrates of protein kinases. 1994, Pubmed
Songyang, SH2 domains recognize specific phosphopeptide sequences. 1993, Pubmed
Stein-Gerlach, Protein-tyrosine phosphatase 1D modulates its own state of tyrosine phosphorylation. 1995, Pubmed
Sugimoto, Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. 1993, Pubmed
Sugimoto, Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. 1994, Pubmed
Tang, The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. 1995, Pubmed , Xenbase
Tauchi, The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. 1994, Pubmed
Tauchi, Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. 1995, Pubmed
Tenev, Both SH2 domains are involved in interaction of SHP-1 with the epidermal growth factor receptor but cannot confer receptor-directed activity to SHP-1/SHP-2 chimera. 1997, Pubmed
Tonks, Protein tyrosine phosphatases and the control of cellular signaling responses. 1996, Pubmed , Xenbase
Tonks, From form to function: signaling by protein tyrosine phosphatases. 1996, Pubmed
Townley, Inhibition of the activity of protein tyrosine phosphate 1C by its SH2 domains. 1993, Pubmed
Vogel, Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584. 1996, Pubmed
Vogel, Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. 1993, Pubmed
Waskiewicz, Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. 1995, Pubmed
Welham, Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase. 1994, Pubmed
Xiao, Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. 1994, Pubmed
Yamaguchi, fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. 1994, Pubmed
Yamauchi, Identification of the major SHPTP2-binding protein that is tyrosine-phosphorylated in response to insulin. 1995, Pubmed
Yamauchi, Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. 1995, Pubmed
Yamauchi, Epidermal growth factor-induced association of the SHPTP2 protein tyrosine phosphatase with a 115-kDa phosphotyrosine protein. 1995, Pubmed