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XB-ART-15705
Gene October 24, 1997; 200 (1-2): 25-34.

Anf: a novel class of vertebrate homeobox genes expressed at the anterior end of the main embryonic axis.

Kazanskaya OV , Severtzova EA , Barth KA , Ermakova GV , Lukyanov SA , Benyumov AO , Pannese M , Boncinelli E , Wilson SW , Zaraisky AG .


Abstract
Five novel genes homologous to the homeobox-containing genes Xanf-1 and Xanf-2 of Xenopus and Hesx-1/Rpx of mouse have been identified as a result of a PCR survey of cDNA in sturgeon, zebrafish, newt, chicken and human. Comparative analysis of the homeodomain primary structure of these genes revealed that they belong to a novel class of homeobox genes, which we name Anf. All genes of this class investigated so far have similar patterns of expression during early embryogenesis, characterized by maximal transcript levels being present at the anterior extremity of the main embryonic body axis. The data obtained also suggest that, despite considerable high structural divergence between their homeodomains, all known Anf genes may be orthologues, and thus represent one of the most quickly evolving classes of vertebrate homeobox genes.

PubMed ID: 9373136
Article link: Gene
Grant support: [+]
Genes referenced: frzb2 hesx1 nppa otx2


Article Images: [+] show captions


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