XB-ART-15771
Curr Opin Genet Dev
1997 Oct 01;75:620-7. doi: 10.1016/s0959-437x(97)80009-3.
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Markers of vertebrate mesoderm induction.
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Mesoderm formation is the first major differentiative event in vertebrate development. Many new mesoderm-specific genes have recently been described in the mouse, chick, frog and fish and belong to classes comprising T-domain genes, homeobox genes and those encoding secreted proteins. The T-domain genes have different but overlapping expression patterns and, in Xenopus, can ectopically activate nearly all other mesodermal genes. Several new homebox genes seem to mediate the ventralising activity of bone morphogenetic protein. New genes encoding secreted proteins induce dorsal mesoderm, in some cases by antagonizing ventralising factors.
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Species referenced: Xenopus
Genes referenced: admp bmp4 cdx2 cdx4 cer1 chrd eomes evx1 foxa4 frzb fst gsc lhx1 meox2 mix1 nodal nodal1 nodal2 nodal3.1 nog not otx2 pou3f4 sia1 tbxt vegt ventx1 ventx2.2 wnt8a xpo1