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XB-ART-15873
Arch Biochem Biophys 1997 Oct 01;3461:1-6. doi: 10.1006/abbi.1997.0283.
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Isolation and characterization of Xenopus laevis xSox-B1 cDNA.

Sakai Y , Hiraoka Y , Konishi M , Ogawa M , Aiso S .


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A family of genes related to the sex-determining region Y gene (SRY) has been termed SOX, and the members are known to encode transcriptional factors and be involved in animal development. We have isolated and sequenced a novel Sox cDNA of Xenopus laevis in this study. The cDNA encodes a protein of 309 amino acids, which encompasses a B-type SOX HMG box; the cDNA was named xSox-B1 in this study. The xSox-B1 mRNA is 1.6 kb in length. Various tissues of adult frog were tested for xSox-B1 mRNA by reverse transcription/ polymerase chain reaction, and the results showed that xSox-B1 expression was highly restricted to the ovary. The message of the xSox-B1 gene was also detected in unfertilized eggs and the late blastula embryos of X. laevis. Recombinant polypeptide of the xSox-B1 HMG domain preferentially binds to the AACAAT sequence.

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Species referenced: Xenopus laevis
Genes referenced: sox13 sox3