Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Genes Dev
1997 Aug 15;1116:2112-23. doi: 10.1101/gad.11.16.2112.
Show Gene links
Show Anatomy links
Autonomous and nonautonomous regulation of axis formation by antagonistic signaling via 7-span cAMP receptors and GSK3 in Dictyostelium.
Ginsburg GT
,
Kimmel AR
.
???displayArticle.abstract???
Early during Dictyostelium development a fundamental cell-fate decision establishes the anteroposterior (prestalk/prespore) axis. Signaling via the 7-transmembrane cAMP receptor CAR4 is essential for creating and maintaining a normal pattern; car4-null alleles have decreased levels of prestalk-specific mRNAs but enhanced expression of prespore genes. car4- cells produce all of the signals required for prestalk differentiation but lack an extracellular factor necessary for prespore differentiation of wild-type cells. This secreted factor decreases the sensitivity of prespore cells to inhibition by the prestalk morphogen DIF-1. At the cell autonomous level, CAR4 is linked to intracellular circuits that activate prestalk but inhibit prespore differentiation. The autonomous action of CAR4 is antagonistic to the positive intracellular signals mediated by another cAMP receptor, CAR1 and/or CAR3. Additional data indicate that these CAR-mediated pathways converge at the serine/threonine protein kinase GSK3, suggesting that the anterior (prestalk)/posterior (prespore) axis of Dictyostelium is regulated by an ancient mechanism that is shared by the Wnt/Fz circuits for dorsoventral patterning during early Xenopus development and establishing Drosophila segment polarity.
???displayArticle.pubmedLink???
9284050
???displayArticle.pmcLink???PMC316452 ???displayArticle.link???Genes Dev
Abe,
A new class of rapidly developing mutants in Dictyostelium discoideum: implications for cyclic AMP metabolism and cell differentiation.
1983, Pubmed
Abe,
A new class of rapidly developing mutants in Dictyostelium discoideum: implications for cyclic AMP metabolism and cell differentiation.
1983,
Pubmed
Alcedo,
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.
1996,
Pubmed
Balint-Kurti,
rZIP, a RING-leucine zipper protein that regulates cell fate determination during Dictyostelium development.
1997,
Pubmed
Berks,
Combinatorial control of cell differentiation by cAMP and DIF-1 during development of Dictyostelium discoideum.
1990,
Pubmed
Bhanot,
A new member of the frizzled family from Drosophila functions as a Wingless receptor.
1996,
Pubmed
Chen,
Signaling through chemoattractant receptors in Dictyostelium.
1996,
Pubmed
Cook,
Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.
1996,
Pubmed
Firtel,
Integration of signaling information in controlling cell-fate decisions in Dictyostelium.
1995,
Pubmed
Franke,
Cyclic nucleotide phosphodiesterase of Dictyostelium discoideum and its glycoprotein inhibitor: structure and expression of their genes.
1991,
Pubmed
Ginsburg,
Inositol trisphosphate and diacylglycerol can differentially modulate gene expression in Dictyostelium.
1989,
Pubmed
Ginsburg,
The regulation of Dictyostelium development by transmembrane signalling.
1995,
Pubmed
Gollop,
Control of cell-type specific gene expression in Dictyostelium by the general transcription factor GBF.
1997,
Pubmed
Gomer,
Cell-autonomous determination of cell-type choice in Dictyostelium development by cell-cycle phase.
1987,
Pubmed
Harwood,
Culmination in Dictyostelium is regulated by the cAMP-dependent protein kinase.
1992,
Pubmed
Harwood,
Glycogen synthase kinase 3 regulates cell fate in Dictyostelium.
1995,
Pubmed
He,
A member of the Frizzled protein family mediating axis induction by Wnt-5A.
1997,
Pubmed
,
Xenbase
He,
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.
1995,
Pubmed
,
Xenbase
Hedgepeth,
Activation of the Wnt signaling pathway: a molecular mechanism for lithium action.
1997,
Pubmed
,
Xenbase
Insall,
DIF-1 induces its own breakdown in Dictyostelium.
1992,
Pubmed
Insall,
Two cAMP receptors activate common signaling pathways in Dictyostelium.
1994,
Pubmed
Johnson,
The cyclic nucleotide specificity of three cAMP receptors in Dictyostelium.
1992,
Pubmed
Johnson,
Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development.
1993,
Pubmed
Kay,
Cell differentiation in monolayers and the investigation of slime mold morphogens.
1987,
Pubmed
Kay,
Chlorine-containing compounds produced during Dictyostelium development. Detection by labelling with 36Cl.
1992,
Pubmed
Kimmel,
Different molecular mechanisms for cAMP regulation of gene expression during Dictyostelium development.
1987,
Pubmed
Kimmel,
cAMP signal transduction pathways regulating development of Dictyostelium discoideum.
1991,
Pubmed
Klein,
A chemoattractant receptor controls development in Dictyostelium discoideum.
1988,
Pubmed
Klein,
A molecular mechanism for the effect of lithium on development.
1996,
Pubmed
,
Xenbase
Krasnow,
A single frizzled protein has a dual function in tissue polarity.
1994,
Pubmed
Leyns,
Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.
1997,
Pubmed
,
Xenbase
Loomis,
Genetic networks that regulate development in Dictyostelium cells.
1996,
Pubmed
Loomis,
Lateral inhibition and pattern formation in Dictyostelium.
1993,
Pubmed
Louis,
Two transmembrane signaling mechanisms control expression of the cAMP receptor gene CAR1 during Dictyostelium development.
1993,
Pubmed
Louis,
The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium.
1994,
Pubmed
Maeda,
Transition of starving Dictyostelium cells to differentiation phase at a particular position of the cell cycle.
1989,
Pubmed
Maeda,
Influence of ionic conditions on cell differentiation and morphogenesis of the cellular slime molds.
1970,
Pubmed
Mann,
cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development.
1993,
Pubmed
Miller,
Signal transduction through beta-catenin and specification of cell fate during embryogenesis.
1996,
Pubmed
Perrimon,
Serpentine proteins slither into the wingless and hedgehog fields.
1996,
Pubmed
Perrimon,
The genetic basis of patterned baldness in Drosophila.
1994,
Pubmed
Pierce,
Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3.
1995,
Pubmed
,
Xenbase
Pupillo,
Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.
1992,
Pubmed
Richardson,
Progression of an inductive signal activates sporulation in Dictyostelium discoideum.
1994,
Pubmed
Saxe,
Expression of a cAMP receptor gene of Dictyostelium and evidence for a multigene family.
1991,
Pubmed
Saxe,
Multiple genes for cell surface cAMP receptors in Dictyostelium discoideum.
1991,
Pubmed
Saxe,
CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum.
1993,
Pubmed
Saxe,
The cAMP receptor subtype cAR2 is restricted to a subset of prestalk cells during Dictyostelium development and displays unexpected DIF-1 responsiveness.
1996,
Pubmed
Shaulsky,
A multidrug resistance transporter/serine protease gene is required for prestalk specialization in Dictyostelium.
1995,
Pubmed
Soede,
Extracellular cAMP depletion triggers stalk gene expression in Dictyostelium: disparities in developmental timing and dose dependency indicate that prespore induction and stalk repression by cAMP are mediated by separate signaling pathways.
1996,
Pubmed
Soede,
Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two subtypes of early cAMP receptors (cARs). Evidence for involvement of cAR1 in aggregative gene expression.
1994,
Pubmed
Spek,
Opposite effects of adenosine on two types of cAMP-induced gene expression in Dictyostelium indicate the involvement of at least two different intracellular pathways for the transduction of cAMP signals.
1988,
Pubmed
Stambolic,
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells.
1996,
Pubmed
,
Xenbase
Sun,
Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium.
1991,
Pubmed
Theibert,
Adenosine and its derivatives inhibit the cAMP signaling response in Dictyostelium discoideum.
1984,
Pubmed
Torres,
Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development.
1996,
Pubmed
,
Xenbase
Van Lookeren Campagne,
Lithium respecifies cyclic AMP-induced cell-type specific gene expression in Dictyostelium.
1988,
Pubmed
Wang,
Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8.
1997,
Pubmed
,
Xenbase
Weijer,
Dependence of cell-type proportioning and sorting on cell cycle phase in Dictyostelium discoideum.
1984,
Pubmed
Williams,
Origins of the prestalk-prespore pattern in Dictyostelium development.
1989,
Pubmed
Williams,
Morphogenesis in Dictyostelium: new twists to a not-so-old tale.
1995,
Pubmed
Yu,
Differential distribution of cAMP receptors cAR2 and cAR3 during Dictyostelium development.
1996,
Pubmed
van den Heuvel,
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling.
1996,
Pubmed
