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XB-ART-16517
Biochim Biophys Acta 1997 May 02;13521:13-7.
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cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF).

Kapelle M , Krätzschmar J , Husemann M , Schleuning WD .


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Germ cell nuclear factor (GCNF) was initially described in the mouse as a germ cell-specific orphan member of the nuclear receptor superfamily. Two full-length cDNAs encoding variants of the human germ cell nuclear factor (GCNF) differing by only one amino acid residue have now been isolated from a human testis cDNA library and characterised. The encoded proteins show 98.3% and 82.7% amino acid identity with mouse and Xenopus GCNF, respectively. Northern blot hybridisation revealed the expression of an 8 kb human GCNF mRNA exclusively in the testis. The alignment of the GCNF protein sequence with other members of the nuclear hormone receptor family suggests an unusual structural organisation of the C-terminal portion of the putative ligand-binding domain.

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Species referenced: Xenopus
Genes referenced: nr6a1