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Mech Dev May 1, 1997; 63 (2): 211-25.
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A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm.

Marine JC , Bellefroid EJ , Pendeville H , Martial JA , Pieler T .

Gli-type zinc finger proteins play important regulatory roles in vertebrate and invertebrate embryogenesis. In Xenopus, the Gli-type proteins XGli-3 and XGli-4 are first expressed in earliest stages of mesoderm and neural development. Transient transfection assays reveal that XGli-3 and XGli-4 can function as transcription repressors. Counteracting the Gli-protein repressor activity by ectopic expression of a fusion protein that contains the Gli-zinc finger cluster connected to the E1A activator domain in Xenopus embryos results in specific morphological alterations in the developing somites and in the central nervous system. Altered expression characteristics for a broad set of molecular markers highlighting specific aspects of mesodermal and neural differentiation demonstrate an important role for Gli-type zinc finger proteins in the early mesodermal and neural patterning of Xenopus embryos.

PubMed ID: 9203143
Article link: Mech Dev

Species referenced: Xenopus
Genes referenced: actl6a egr2 gli3 h4c4 lgals4.2 mst1 myod1 myt1 neurod1 pax6 slc5a5 tbx2 tub tubb2b tyro3

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