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XB-ART-16621
Dev Biol April 15, 1997; 184 (2): 367-72.

Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer.



Abstract
We have isolated a novel TGF beta-like gene from Xenopus which is highly related to mouse nodal The gene, Xnr4, is expressed at the gastrula stage in the Spemann organizer and at later stages in the notochord and neural tube. Ectopic expression of Xnr4 can induce and dorsalize mesoderm. These studies suggest that Xnr4, along with other nodal-related genes (Xnr1-3), may participate in mesodermal patterning and possibly neural development.

PubMed ID: 9133442
Article link: Dev Biol

Genes referenced: acta4 actc1 agtr1 gsc nodal nodal1 nog sia1 tbxt tgfb1 wnt8a


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