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The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells.
Collier B
,
Gorgoni B
,
Loveridge C
,
Cooke HJ
,
Gray NK
.
???displayArticle.abstract??? DAZL proteins are germ-cell-specific RNA-binding proteins essential for gametogenesis. The precise molecular role of these proteins in germ-cell development remains enigmatic; however, they appear to function in the cytoplasm. In order to directly address the function of vertebrate DAZL proteins, we have used Xenopus laevis oocytes as a model system. Here we demonstrate that members of this family, including Xdazl, mouse Dazl, human DAZL, human DAZ and human BOULE, have the ability to stimulate translation and function at the level of translation initiation. We show that DAZL proteins interact with poly(A)-binding proteins (PABPs), which are critical for the initiation of translation. Mapping and tethered function experiments suggest that these interactions are physiologically important. This leads to an attractive hypothesis whereby DAZL proteins activate translationally silent mRNAs during germ cell development through the direct recruitment of PABPs.
Cheng,
Biphasic subcellular localization of the DAZL-related protein boule in Drosophila spermatogenesis.
1998, Pubmed
Cheng,
Biphasic subcellular localization of the DAZL-related protein boule in Drosophila spermatogenesis.
1998,
Pubmed
Collier,
Specific inactivation of inhibitory sequences in the 5' end of the human papillomavirus type 16 L1 open reading frame results in production of high levels of L1 protein in human epithelial cells.
2002,
Pubmed
Cosson,
Characterization of the poly(A) binding proteins expressed during oogenesis and early development of Xenopus laevis.
2002,
Pubmed
,
Xenbase
Eberhart,
Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia.
1996,
Pubmed
Elliott,
RBMY genes and AZFb deletions.
2000,
Pubmed
Fox,
Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind.
2005,
Pubmed
,
Xenbase
Gillian-Daniel,
Modifications of the 5' cap of mRNAs during Xenopus oocyte maturation: independence from changes in poly(A) length and impact on translation.
1998,
Pubmed
,
Xenbase
Gorgoni,
The roles of cytoplasmic poly(A)-binding proteins in regulating gene expression: a developmental perspective.
2004,
Pubmed
Gorgoni,
The stem-loop binding protein stimulates histone translation at an early step in the initiation pathway.
2005,
Pubmed
,
Xenbase
Gray,
Control of translation initiation in animals.
1998,
Pubmed
Gray,
Multiple portions of poly(A)-binding protein stimulate translation in vivo.
2000,
Pubmed
,
Xenbase
Haag,
Rolling back to BOULE.
2001,
Pubmed
Houston,
A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule.
1998,
Pubmed
,
Xenbase
Houston,
A critical role for Xdazl, a germ plasm-localized RNA, in the differentiation of primordial germ cells in Xenopus.
2000,
Pubmed
,
Xenbase
Jiao,
Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein.
2002,
Pubmed
Karashima,
Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis.
2000,
Pubmed
Kashiwabara,
Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP.
2002,
Pubmed
Kühn,
Xenopus poly(A) binding protein: functional domains in RNA binding and protein-protein interaction.
1996,
Pubmed
,
Xenbase
Ma,
A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.
1993,
Pubmed
Macdonald,
Diversity in translational regulation.
2001,
Pubmed
Maegawa,
Zebrafish DAZ-like protein controls translation via the sequence 'GUUC'.
2002,
Pubmed
Maines,
Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule.
1999,
Pubmed
Mita,
Expression of Xenopus Daz-like protein during gametogenesis and embryogenesis.
2000,
Pubmed
,
Xenbase
Moore,
Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.
2003,
Pubmed
Moore,
Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells.
2004,
Pubmed
Nakamura,
Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.
2004,
Pubmed
Nelson,
Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression.
2004,
Pubmed
Reijo,
DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice.
2000,
Pubmed
Reijo,
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.
1995,
Pubmed
Ruggiu,
The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.
1997,
Pubmed
Seli,
An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.
2005,
Pubmed
,
Xenbase
Slee,
A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype.
1999,
Pubmed
Tiepolo,
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
1976,
Pubmed
Tsui,
Association of the mouse infertility factor DAZL1 with actively translating polyribosomes.
2000,
Pubmed
Tsui,
Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.
2000,
Pubmed
Venables,
The RNA-binding specificity of the mouse Dazl protein.
2001,
Pubmed
Vidal,
Yeast forward and reverse 'n'-hybrid systems.
1999,
Pubmed
Voeltz,
A novel embryonic poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg extracts.
2001,
Pubmed
,
Xenbase
Vogel,
Partial rescue of the Dazl knockout mouse by the human DAZL gene.
2002,
Pubmed
Vogt,
Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11.
1996,
Pubmed
Wickens,
A PUF family portrait: 3'UTR regulation as a way of life.
2002,
Pubmed
Wilhelm,
Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz.
2003,
Pubmed
Wilkie,
Regulation of mRNA translation by 5'- and 3'-UTR-binding factors.
2003,
Pubmed
Wilkie,
Embryonic poly(A)-binding protein stimulates translation in germ cells.
2005,
Pubmed
,
Xenbase
Xu,
Human BOULE gene rescues meiotic defects in infertile flies.
2003,
Pubmed
Yen,
The human DAZ genes, a putative male infertility factor on the Y chromosome, are highly polymorphic in the DAZ repeat regions.
1997,
Pubmed
Zhang,
Yeast three-hybrid system to detect and analyze interactions between RNA and protein.
1999,
Pubmed
de Kretser,
Male infertility.
1997,
Pubmed
