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XB-ART-16884
Dev Biol February 15, 1997; 182 (2): 314-30.

ADAM 13: a novel ADAM expressed in somitic mesoderm and neural crest cells during Xenopus laevis development.

Alfandari D , Wolfsberg TG , White JM , DeSimone DW .


Abstract
Embryonic development involves a series of cell adhesive interactions that provide mechanical and instructive information required for morphogenesis. The ADAMs family of membrane-anchored proteins, containing a disintegrin and metalloprotease domain, is well suited for participating in such developmental events. They encode not only a potential adhesive function, through an integrin-binding disintegrin domain, but also a potential antiadhesive function, through a zinc-dependent metalloprotease domain. In order to investigate the role of ADAMs in early development we cloned a cDNA encoding a novel member of the ADAM family from a Xenopus laevis neurula stage library. We call this cDNA, and the 915-amino-acid protein it encodes, ADAM 13, X-ADAM 13 RNA is expressed during embryogenesis from the midblastula stage through tadpole stage 45. X-ADAM 13 is localized to somitic mesoderm and cranial neural crest cells during gastrulation, neurulation, and in tail bud stages. Sequence analyses of the X-ADAM 13 metalloprotease and disintegrin domains indicate that the protein is likely to be involved in both proteolytic and cell-adhesive functions. The X-ADAM 13 sequence is most closely related to that of mouse meltrin alpha, which is implicated in myoblast fusion. Our data suggest that X-ADAM 13 may be involved in neural crest cell adhesion and migration as well as myoblast differentiation.

PubMed ID: 9070330
Article link: Dev Biol
Grant support: [+]
Genes referenced: adam12 adam28.2 adam33 adam9 fn1
Antibodies: Adam33 Ab1 Fn1 Ab1


Article Images: [+] show captions


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