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XB-ART-16943
Dev Growth Differ 1997 Feb 01;391:111-5. doi: 10.1046/j.1440-169x.1997.00012.x.
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Inhibition of gastrulation in Xenopus embryos by an antibody against a cathepsin L-like protease.

Miyata S , Kubo T .


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An antibody against cathepsin L-like protease (AACLP) was injected into one cell of 2-celled Xenopus embryos. The blastopores of AACLP-injected embryos either did not invaginate or failed to complete invagination. As a result of this failure to complete gastrulation, the body axes could not form normally and tail bud stage embryos were bent dorsally. Embryos injected with a control antibody (CA) developed normally through the tadpole stage. Mesodermal induction was not inhibited in embryos exhibiting this AACLP-induced gastrulation defect, but the mesodermal structure of these embryos was organized incorrectly due to the defective gastrulation during the early stages.

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Species referenced: Xenopus laevis
Genes referenced: ctsl