Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-16979
Curr Opin Neurobiol February 1, 1997; 7 (1): 7-12.

Neural induction in Xenopus laevis: evidence for the default model.



Abstract
At gastrulation, vertebrate ectoderm is competent to differentiate into either neural tissue or epidermis. Several soluble factors that can neuralize ectoderm in explant cultures have been isolated. Alternatively, neuralization can be achieved by dissociating the cells of the blastula ectoderm. These various treatments appear to neuralize by blocking or diluting out the action of an epidermal-inducing factor. Recent results demonstrate that bone morphogenetic protein 4 (BMP-4), a member of the transforming growth factor beta (TGF-beta) ligand superfamily, is a potent neural inhibitor and epidermal inducer and may represent the endogenous epidermal-inducing factor.

PubMed ID: 9039789
Article link: Curr Opin Neurobiol
Grant support: [+]