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Dev Biol. January 15, 1997; 181 (2): 223-33.

Xbap, a vertebrate gene related to bagpipe, is expressed in developing craniofacial structures and in anterior gut muscle.

Newman CS , Grow MW , Cleaver O , Chia F , Krieg P .

The Drosophila bagpipe (bap) gene is involved in the specification of the musculature of the embryonic midgut. We report the isolation and characterization of a Xenopus sequence, Xbap, which is closely related to bap. Xbap is also expressed in the developing musculature of the midgut, suggesting that this developmental role of bagpipe is evolutionarily conserved. However, a second, novel role in development is suggested by the observation that Xbap is also expressed in a region of the developing facial cartilage. Using a combination of cartilage staining and comparison to the goosecoid head expression pattern, we show that Xbap expression marks the precursors to the basihyobranchial, palatoquadrate, and possibly Meckel''s cartilages. This vertebrate bagpipe sequence therefore is expressed in both mesodermally and neural crest-derived tissues.

PubMed ID: 9013932
Article link: Dev Biol.
Grant support: HD25179 NICHD NIH HHS , HL52746 NHLBI NIH HHS

Genes referenced: frzb2 gsc nkx2-5 nkx3-1 nkx3-2

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