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XB-ART-1717
Dev Biol July 1, 2005; 283 (1): 17-28.

xBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development.



Abstract
In Xenopus, two signaling systems, maternal beta-Catenin and Nodal-related, are required for induction of the Spemann organizer and establishment of the body plan. By screening cDNA macroarrays for genes activated by these two signaling pathways, we identified Xenopus xBtg-x, a novel member of the Btg/Tob gene family of antiproliferative proteins. We show that xBtg-x is expressed in the dorsal mesendoderm (Spemann organizer tissue) of gastrula stage embryos and that its expression is regulated by both beta-Catenin and Nodal-related signals. Microinjection of synthetic xBtg-x mRNA into Xenopus embryos induced axis duplication and completely rescued the ventralizing effects of UV irradiation through the activation of the canonical Wnt/beta-Catenin signaling pathway. Interestingly, xBtg-x stimulated beta-Catenin-dependent transcription without affecting the stability of beta-Catenin protein. These data suggest that xBtg-x is a novel component of the Wnt/beta-Catenin signaling pathway regulating early embryonic patterning.

PubMed ID: 15975429
PMC ID: PMC2278116
Article link: Dev Biol
Grant support: [+]
Genes referenced: acvr1 btg5.2 btg5.3 cer1 chrd.1 ctnnb1 egr2 hoxb9 hoxc9-like myc nlk nodal nodal1 nodal3.1 odc1 otx2 pax3 snai2 sox2 tbx2 tcf7l1
Morpholinos: btg-x MO1 btg-x MO2


Article Images: [+] show captions
References:
Agius, 2000, Pubmed, Xenbase [+]


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