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Development January 1, 1997; 124 (2): 515-23.

Retinoid receptors promote primary neurogenesis in Xenopus.

Sharpe CR , Goldstone K .

Retinoid receptors, which are members of the nuclear hormone receptor superfamily, act as ligand-dependent transcription factors. They mediate the effects of retinoic acid primarily as heterodimers of retinoic acid receptors (RARs) and retinoid X receptors (RXRs). To analyse their function, xRXR beta synthetic mRNA was injected into Xenopus embryos in combination with normal and mutated xRAR alpha transcripts. Two informative phenotypes are reported here. Firstly, over-expression of xRXR beta with xRAR alpha results in the formation of ectopic primary neurons. Secondly, blocking retinoid signalling with a mutated xRAR alpha results in a lack of primary neurons. These two phenotypes, from contra-acting manipulations, indicate a role for retinoid signalling during neurogenesis.

PubMed ID: 9053327
Article link: Development

Genes referenced: b3gat1l elavl1 prph rarb rxrb
Antibodies: B3gat1 Ab2

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